CONDITIONAL KNOCKOUT OF RAD51-RELATED GENES IN LEISHMANIA MAJOR REVEALS A CRITICAL ROLE FOR HOMOLOGOUS RECOMBINATION DURING GENOME REPLICATION.

Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication.

Homologous recombination (HR) has an intimate relationship with genome replication, both during repair of DNA lesions that might prevent DNA synthesis and in tackling stalls to the replication fork.Recent studies led us to ask if HR might have a more central role in replicating the genome of Leishmania, a eukaryotic parasite.Conflicting evidence ha

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Role of Genetic Testing and Complex Endoscopic Examination in Differential Diagnosis of Hereditary Polyposes in Pediatric and Adolescent Patients: 10 Years Clinical Experience

Background.Hereditary polyposis syndromes (HPS) are a group of rare genetic diseases characterized by multiple epithelial lesions in the gastrointestinal tract (GIT) with high risk of malignancy and neoplasia development in other localizations.The case follow-up tactics in hereditary polyposes have significant differences, and differential diagnosi

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Casertavecchia: dal progetto di restauro urbano di Roberto Pane ed Ezio De Felice al frammentario restauro del castello medievale

In 1954 the architects Roberto Pane and Ezio De Felice were commissioned by the Caserta Provincial Tourist Board to draw up the restoration project of the medieval village of Casertavecchia.After some modifications were made, in 1961 the project was financed by the Cassa per il Mezzogiorno.The plan was not limited to the restoration of the architec

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